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Rivotril poate fi administrat concomitent cu unul sau mai multe antiepileptice. Adaugarea la regimul terapeutic a unui alt medicament antiepileptic necesita evaluarea atenta a raspunsului la tratament, deoarece reactiile adverse, cum sunt sedarea si apatia apar mai frecvent in aceasta situatie.EMA ble opprettet i 1995 for å sikre ideal mulig utnyt